Medical Use
Exkivity is a kinase inhibitor used to treat adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations, whose cancer has progressed after platinum-based chemotherapy.
Recommended Dosage: The recommended dose is 160 mg taken orally once daily until disease progression or unacceptable toxicity occurs. Exkivity capsules can be taken with or without food, consistently at the same time each day. Swallow the capsules whole without opening, chewing, or dissolving them.
If a dose is missed by more than 6 hours, skip that dose and take the next dose at the regular time the following day. If a dose is vomited, do not take an additional dose; instead, take the next scheduled dose as prescribed the following day.
Warning & Precautions
QTc Prolongation: Mobocertinib can cause severe QTc prolongation, including Torsades de Pointes, which may be fatal. Assess QTc and correct electrolyte imbalances (potassium, sodium, calcium, magnesium) before starting treatment. Monitor electrolytes and QTc regularly, especially in patients with risk factors like congenital long QT syndrome, heart disease, or electrolyte abnormalities. Avoid using other medications that prolong the QTc interval.
ILD/Pneumonitis: Mobocertinib can cause interstitial lung disease (ILD) or pneumonitis, which may be fatal. Monitor for new or worsening pulmonary symptoms. If ILD/pneumonitis is suspected, withhold treatment and discontinue permanently if confirmed.
Cardiac Toxicity: Mobocertinib can lead to cardiac toxicity, including heart failure, which could be fatal. Monitor cardiac function, including left ventricular ejection fraction, during treatment. Adjust the dose or discontinue based on severity.
Diarrhea: Mobocertinib can cause severe diarrhea. Patients should start an antidiarrheal agent at the first sign of diarrhea or increased bowel movements and increase fluid and electrolyte intake. Monitor electrolytes and adjust the dose or discontinue treatment based on severity.
Fetal Harm: Mobocertinib can cause fetal harm based on animal studies and its mechanism of action. Advise women not to breastfeed during treatment and for 7 days after the final dose.
Documentation Availability
EXKIVITY (Mobocertinib) Capsules can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing EXKIVITY (Cancer Treatment Medicines) from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the generic name for the trade name drug Exkivity®?
The generic name for Exkivity® is mobocertinib.
Who manufactures Exkivity®?
Exkivity® is manufactured by Takeda Pharmaceutical Company Limited.
Is Exkivity® FDA approved?
Yes, Exkivity® was approved by the FDA on September 15, 2021.
What is Exkivity®?
Exkivity® is a first-in-class, oral tyrosine kinase inhibitor (TKI) designed to treat adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC).
What dosage and form is Exkivity® available in?
Exkivity® is available as 40 mg capsules for oral administration.
What are the most common side effects of Exkivity®?
Common side effects of Exkivity® include rash, diarrhea, nausea, mouth sores, vomiting, fatigue, decreased appetite, nail infections, dry skin, and musculoskeletal pain.
How much does mobocertinib cost in India?
The cost of mobocertinib in India is reasonable. To purchase this NSCLC medication legally, you can reach out to Rx4u team.
What are the storage conditions for Exkivity®?
Store Exkivity® capsules at 20°C to 25°C (68°F to 77°F), with allowed excursions between 15°C and 30°C (59°F to 86°F).
Is it safe to buy Exkivity® online in India?
Yes, you can safely purchase Exkivity® online in India through https://rx4u.in/.
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