Medical Use
Rylaze is an enzyme specifically targeting asparagine, used as part of a multi-agent chemotherapy regimen to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) in both adults and children aged one month or older who are allergic to E. coli-derived asparaginase.
Recommended Dosage: When substituting a long-acting asparaginase product, the recommended dose is 25 mg/m², administered intramuscularly every 48 hours.
Warning & Precautions
Severe Allergic Reactions: Due to the risk of life-threatening anaphylaxis, administer this recombinant injection in a setting equipped with resuscitation tools and other agents needed to treat anaphylaxis. Discontinue therapy in patients who experience severe hypersensitivity reactions.
Thrombotic Events: Severe thrombotic events, such as sagittal sinus thrombosis and pulmonary embolism, have been reported with L-asparaginase class products. Discontinue Rylaze if a thrombotic event occurs and provide appropriate antithrombotic therapy. Consider resuming Rylaze only if the thrombosis was uncomplicated.
Pancreatitis: Pancreatitis has been reported in patients treated with Rylaze. Evaluate patients with symptoms of pancreatitis to confirm the diagnosis. Monitor serum amylase and lipase levels in patients showing signs or symptoms of pancreatitis.
Hemorrhage: Hemorrhage, associated with increased partial thromboplastin time (PTT), increased prothrombin time (PT), and hypofibrinogenemia, may occur in patients treated with asparaginase products. Provide appropriate replacement therapy for patients with severe or symptomatic coagulopathy.
Liver Toxicity: Elevated bilirubin or transaminases have been observed in patients treated with Rylaze. Monitor bilirubin and transaminases before treatment and every 2 to 3 weeks during treatment. Discontinue Rylaze and provide supportive care if severe liver toxicity occurs.
Documentation Availability
Documents required to import RYLAZE to India?
RYLAZE (asparaginase erwinia chrysanthemi) injections can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing RYLAZE (asparaginase erwinia chrysanthemi) injections from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the generic name for the trade name drug Rylaze®?
The generic name for Rylaze® is Asparaginase Erwinia Chrysanthemi (recombinant)-rywn.
Who manufactures Rylaze®?
Rylaze® is manufactured by Jazz Pharmaceuticals.
Is Rylaze® FDA approved?
Yes, Rylaze® was approved by the FDA on June 30, 2021.
What is Rylaze 10 mg Injection?
Rylaze 10 mg injection, previously known as JZP458, is an asparagine-specific enzyme used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) in certain adult and pediatric patients.
What dosage and form is Rylaze® available in?
Rylaze® is available as an injection: 10 mg/0.5 mL solution in a single-dose vial for intramuscular administration.
What are the most common side effects of Rylaze®?
Common side effects of Rylaze® include drug hypersensitivity, fever, abnormal liver tests, nausea, musculoskeletal pain, fatigue, infection, headache, febrile neutropenia, mouth sores, decreased appetite, bleeding, and high blood sugar.
How much does Rylaze® cost in India?
The cost of Rylaze® in India is quite reasonable. To purchase this medication legally, you can reach out to Rx4u team.
What are the storage conditions for Rylaze®?
Store Rylaze® vials refrigerated at 2-8°C (36-46°F) in their original carton to protect from light. Do not shake or freeze.
Is it safe to buy Rylaze® online in India?
Yes, you can safely purchase Rylaze® online in India through https://rx4u.in/.
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