Medical Use
Epidiolex is prescribed for managing seizures in patients aged 12 months and older who have Lennox-Gastaut syndrome, Dravet syndrome, or Tuberous sclerosis complex.
Recommended Dosage:
- -Before Treatment: Check serum transaminases (ALT and AST) and total bilirubin levels.
For Seizures Associated with Lennox-Gastaut Syndrome or Dravet Syndrome:
- -Initial Dose: 2.5 mg/kg orally twice daily (5 mg/kg/day).
- -After 7 Days: Increase to a maintenance dose of 5 mg/kg twice daily (10 mg/kg/day).
- -Maximum Dose: Can be increased up to 10 mg/kg twice daily (20 mg/kg/day) based on clinical response and tolerability.
For Seizures Associated with Tuberous Sclerosis Complex (TSC):
- -Initial Dose: 2.5 mg/kg orally twice daily (5 mg/kg/day).
- -Weekly Increments: Increase by 2.5 mg/kg twice daily (5 mg/kg/day) to a maintenance dose of 12.5 mg/kg twice daily (25 mg/kg/day), as tolerated.
- -Rapid Titration: If needed, increase dosage no more frequently than every other day to reach 25 mg/kg/day.
Note: The effectiveness of doses below 12.5 mg/kg twice daily has not been evaluated for TSC.
Patients with Hepatic Impairment:
- -Dose Adjustment: Required for moderate (Child-Pugh B) or severe (Child-Pugh C) hepatic impairment.
Warning & Precautions
Epidiolex 100mg/mL may cause hypersensitivity reactions. If such reactions occur, discontinue the medication immediately. It should not be used in patients with a known hypersensitivity to cannabidiol or any other ingredients in the product.
Liver Transaminase Elevations: Cannabidiol can cause dose-related increases in liver enzymes (ALT and AST). Before starting treatment, check serum transaminases (ALT/AST) and total bilirubin levels.
Somnolence and Sedation: Cannabidiol may cause drowsiness and sedation. Patients should be monitored for these effects and advised not to drive or operate machinery until they are familiar with how the medication affects them.
Suicidal Thoughts and Behavior: Antiepileptic drugs (AEDs), including Cannabidiol 100mg/mL, can increase the risk of suicidal thoughts or behavior. Patients should be monitored for signs of depression, suicidal thoughts or behavior, or any unusual changes in mood or behavior.
Withdrawal: Cannabidiol should generally be tapered off gradually to avoid increased seizure frequency and status epilepticus. However, in cases of serious adverse events, rapid discontinuation may be necessary.
Pregnancy and Breastfeeding: The safety of Epidiolex during pregnancy and breastfeeding is not established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential benefits and risks with your doctor.
Documentation Availability
Documents required to import EPIDIOLEX to India?
EPIDIOLEX (Cannabidiol) Oral Solution can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing EPIDIOLEX (Cancer Treatment Medicines) from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the Generic Name for Epidiolex®?
The generic name for Epidiolex® is Cannabidiol.
Who Manufactures Epidiolex®?
Epidiolex® is manufactured by GW Pharmaceuticals plc.
Is Epidiolex® FDA Approved?
Yes, Epidiolex® received FDA approval on June 25, 2018.
Where Can I Find the Best Price for Epidiolex® in India?
For the best price on Epidiolex® in India, contact the Rx4u team.
What is the Dosage Form of Epidiolex®?
Epidiolex® is available as a strawberry-flavored liquid oral solution, containing 100 mg of Cannabidiol per mL. It is taken orally twice daily.
What are the Common Side Effects of Epidiolex®?
- For Lennox-Gastaut syndrome or Dravet syndrome: Decreased appetite, somnolence, diarrhea, elevated transaminases, fatigue, malaise, asthenia, rash, sleep disorders, insomnia, poor quality sleep, and infections.
- For Tuberous Sclerosis Complex: Elevated transaminases, diarrhea, decreased appetite, somnolence, fever, and vomiting.
What are the Storage Conditions for Epidiolex®?
Store Epidiolex® upright at 20 to 25°C (68 to 77°F), with permissible excursions between 15°C to 30°C (59°F to 86°F). Do not freeze. Keep the cap tightly closed and use within twelve weeks of opening the bottle. Discard any remaining solution after this period.
Is it Safe to Buy Epidiolex® Online from India?
Yes, you can safely purchase Epidiolex® online in India through https://rx4u.in/.
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