Medical Use
Amondys 45 is an antisense oligonucleotide designed to treat Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation in the DMD gene that allows for exon 45 skipping.
Dosage Recommendations:
- Standard Dose: Administer 30 mg per kilogram of body weight once a week.
- Administration: Infuse intravenously over 35 to 60 minutes using an in-line 0.2 micron filter.
If a dose of Amondys 45 (Casimersen Injection) is missed, it should be administered as soon as possible after the scheduled time.
Warning & Precautions
Before beginning Casimersen therapy, it is essential to measure serum cystatin C, perform a urine dipstick test, and determine the urine protein-to-creatinine ratio (UPCR). Additionally, consider assessing the glomerular filtration rate.
During Casimersen treatment at a dosage of 10 mg, monthly monitoring of the urine dipstick is required, while serum cystatin C and UPCR should be checked every three months.
Given the potential for nephrotoxicity with medications similar to Amondys 45, it is crucial to monitor patients for kidney toxicity throughout the treatment. Ensure urine samples are collected either before the Amondys 45 infusion or at least 48 hours post-infusion.
Documentation Availability
Documents required to import AMONDYS 45 to India?
AMONDYS 45 (casimersen) injection can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing AMONDYS 45 (Cancer Treatment Medicines) from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the generic name for Amondys 45®?
The generic name for Amondys 45® is Casimersen.
Who manufactures Amondys 45®?
Amondys 45® is manufactured by Sarepta Therapeutics, Inc.
Is Amondys 45® approved by the FDA?
Yes, Amondys 45® was approved by the FDA on February 25, 2021.
What is Amondys 45® used for?
Amondys 45® is approved by the FDA to treat patients with Duchenne muscular dystrophy (DMD) who have a confirmed mutation of the dystrophin gene that can be treated by skipping exon 45.
What is the dosage form of Amondys 45®?
Amondys 45® is supplied as an injection: 100 mg/2 mL (50 mg/mL) solution in a single-dose vial for intravenous administration.
How long does the infusion of Amondys 45® take?
The infusion typically takes about 35-60 minutes and is administered via an in-line 0.2 micron filter.
What are the most common side effects of Amondys 45®?
Common side effects include cough, fever, upper respiratory tract infection, headache, joint pain, and throat pain.
How much does Amondys 45® cost in India?
The cost of Amondys 45® in India is considered reasonable. For authentic procurement, you can order from www.rx4u.in
What are the storage conditions for Amondys 45®?
Store Amondys 45® vials at 2°C to 8°C (36°F to 46°F). Do not freeze and keep them in the original carton to protect from light until ready for use.
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