Medical Use
Orfadin (nitisinone) is a medication used to treat hereditary tyrosinemia type 1 (HT-1) in both adults and children. It works by inhibiting the enzyme hydroxy-phenylpyruvate dioxygenase, which prevents the buildup of harmful substances in the body. To effectively manage HT-1, Orfadin is usually prescribed along with a special diet that limits the intake of tyrosine and phenylalanine, essential amino acids. By lowering the levels of toxic substances, Orfadin helps prevent liver and kidney damage associated with HT-1, thereby enhancing the quality of life for patients with this rare genetic disorder.
Recommended Dosage:
- -Starting Dosage: The initial recommended dosage of Orfadin is 0.5 mg/kg, taken orally twice a day.
- -Maintenance Regimen: For patients aged 5 years and older who have undetectable levels of serum and urine succinylacetone after at least 4 weeks on a stable nitisinone dosage, the total daily dose of Orfadin can be administered once daily (e.g., 1 to 2 mg/kg once a day).
Warning & Precautions
Nitisinone can lead to increased plasma tyrosine levels, which may cause eye-related issues such as keratitis, photophobia, and corneal ulcers. To manage these effects, regular monitoring of plasma tyrosine levels is essential, along with dietary restrictions on tyrosine and phenylalanine intake.
Patients might experience visual discomfort and blurred vision. It’s crucial to watch for signs of keratopathy or other ocular disturbances, and seek immediate ophthalmologic evaluation if symptoms arise.
Children, in particular, may show developmental delays and hyperkeratotic plaques. Therefore, growth and neurological development should be closely monitored during treatment.
Orfadin, available in 2 mg, 5 mg, 10 mg, or 20 mg doses, can cause leukopenia and severe thrombocytopenia, increasing the risk of infections and bleeding. Regular blood tests are necessary to detect these conditions early.
During pregnancy, Orfadin should only be used if the potential benefits justify the risks. Breastfeeding is not recommended while taking Orfadin, as it may pass into breast milk and harm the infant.
Caution is advised when using Orfadin with other medications due to potential drug interactions. Always consult a healthcare professional before combining treatments.
Documentation Availability
Documents required to import ORFADIN to India?
ORFADIN (nitisinone) capsules can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing ORFADIN (a cancer treatment medication) from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the Generic Name for Orfadin®?
The generic name for Orfadin® is nitisinone.
Who Manufactures Orfadin®?
Orfadin® is manufactured by Swedish Orphan Biovitrum.
Is Orfadin® FDA Approved?
Yes, Orfadin® received FDA approval on January 18, 2002.
What Dosage Forms are Available for Orfadin®?
Orfadin® is available in capsule form with dosages of 2 mg, 5 mg, 10 mg, and 20 mg for oral administration.
What are the Common Side Effects of Orfadin®?
Common side effects include thrombocytopenia, elevated tyrosine levels, leukopenia, eye pain, conjunctivitis, corneal opacity, keratitis, photophobia, blepharitis, cataracts, granulocytopenia, dry skin, epistaxis, pruritus, exfoliative dermatitis, maculopapular rash, and alopecia.
Where Can I Purchase Orfadin® (Nitisinone) at the Best Price in India?
Orfadin® can be purchased from https://rx4u.in/
How Much Does Orfadin® (Nitisinone) Cost in India?
Prices may vary due to market dynamics and regulatory changes. For the most accurate and up-to-date pricing information, contact Rx4u team.
Is it safe to buy Orfadin® (Nitisinone) online from India?
Yes, You can buy Takhzyro online from India at the best price from https://rx4u.in/
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