Medical Use
Andexanet alfa (known as Andexxa in the U.S. and Ondexxya in the EU) is a recombinant modified human factor Xa (FXa) protein. It is used to stop life-threatening or uncontrolled bleeding in adults who are taking direct FXa inhibitors or anticoagulants, specifically apixaban or rivaroxaban.
Dosage Recommendations: Andexanet alfa should be administered intravenously using a 0.2 or 0.22-micron in-line polyethersulfone or low protein-binding filter. The recommended dosages are:
- -Low Dose: An initial IV bolus of 400 mg at a target rate of 30 mg/min, followed by a continuous infusion of 4 mg/min for up to 120 minutes.
- -High Dose: An initial IV bolus of 800 mg at a target rate of 30 mg/min, followed by a continuous infusion of 8 mg/min for up to 120 minutes.
Warning & Precautions
Thromboembolic and Ischemic Risks: Patients receiving Ondexxya may experience thromboembolic and ischemic events. Monitor for ischemic events, arterial and venous thromboembolic events, and cardiac arrest. To reduce the risk of thromboembolism, resume anticoagulant treatment as soon as medically appropriate after Ondexxya 200 mg therapy.
Interaction with Heparin: Ondexxya may interfere with the anticoagulant effects of heparin. It is not specified for use as a heparin antidote. Avoid using Ondexxya to reverse direct FXa inhibitors (apixaban and rivaroxaban) before heparinization, as it may cause heparin unresponsiveness. If anticoagulation is needed, consider alternatives to heparin.
Infusion Reactions: For mild or moderate infusion reactions, close monitoring may suffice. For moderate symptoms, consider temporarily stopping or slowing the infusion rate, and resume once symptoms subside. Diphenhydramine can be administered if necessary.
Pregnancy and Breastfeeding: The use of Andexxa 200 mg is not recommended during pregnancy or in women of childbearing age not using contraception. Consider discontinuing breastfeeding during treatment with andexanet alfa injection.
Documentation Availability
Documents required to import ONDEXXYA®/ANDEXXA® to India?
ANDEXXA/ONDEXXYA (andexanet alfa) can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing ANDEXXA/ONDEXXYA (Cancer Treatment Medicines) around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is Andexanet alfa?
Andexanet alfa, marketed under the brand names Andexxa and Ondexxya, is an antidote for rivaroxaban and apixaban. It is used to reverse anticoagulation in cases of uncontrolled bleeding. It is not effective for other factor Xa inhibitors.
What is the Generic Name for Andexxa®/Ondexxya®?
The generic name for Andexxa®/Ondexxya® is andexanet alfa.
Who manufactures Andexxa® and Ondexxya®?
Andexxa® is manufactured by Alexion Pharmaceuticals, Inc., while Ondexxya® is produced by Portola Pharmaceuticals UK Ltd.
What is the dosage form of Andexxa®/Ondexxya®?
Andexxa®/Ondexxya® is available as a lyophilized powder for solution in single-use vials of 200 mg for intravenous injection.
What are the common side effects of Andexanet alfa?
Common side effects include infusion-related reactions, urinary tract infections, and pneumonia.
How much does Andexxa®/Ondexxya® cost in India?
The cost of Andexxa®/Ondexxya® in India can vary. To purchase it legally, you can reach out to the Rx4u team.
How should Andexxa®/Ondexxya® be stored?
Store unopened vials of Andexxa®/Ondexxya® in a refrigerator at 2-8°C (36-46°F). Do not freeze.
How to order Andexxa®/Ondexxya® online in India?
Andexxa®/Ondexxya® can be ordered online in India through https://rx4u.in/.
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