Medical Use
Atriance, a nucleoside metabolic inhibitor, is prescribed for patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma, particularly when the disease has not responded to or has relapsed after at least two chemotherapy treatments.
Recommended Dosage:
- -Adults and Adolescents (16 years and older): The suggested dose of Nelarabine for this age group is 1,500 mg/m². This is administered intravenously over two hours on days 1, 3, and 5 of each 21-day treatment cycle. This schedule is designed to enhance the drug’s efficacy while reducing potential side effects.
- -Children and Adolescents (21 years and younger): For younger patients, the recommended dose of Nelarabine injection (250 mg/50 mL, 5 mg/mL) is 650 mg/m². This is given as an intravenous infusion over one hour, once daily, for five consecutive days. The treatment cycle is repeated every 21 days. This regimen aims to balance effectiveness and side effect management, ensuring optimal treatment for young patients.
Warning & Precautions
Patients receiving nelarabine 250 mg/50 mL should be aware of potential neurological side effects, including seizures, peripheral neuropathy, and confusion. Close monitoring for these symptoms is crucial throughout the treatment. If severe neurological issues arise, dosage adjustments or discontinuation of the medication may be necessary.
During nelarabine treatment, it is advisable to avoid live vaccines, as they might be less effective and could increase infection risk. Discuss your vaccination schedule with your healthcare provider before starting nelarabine to ensure safe immunization.
Nelarabine can cause serious blood-related side effects, such as low levels of neutrophils, platelets, and red blood cells. Regular blood count monitoring before and during treatment is essential. Based on the results, dose adjustments or supportive care strategies may be needed to minimize complications.
Patients on nelarabine may also be at risk for tumor lysis syndrome (TLS), characterized by metabolic imbalances like high uric acid (hyperuricemia), potassium (hyperkalemia), and phosphate (hyperphosphatemia), and low calcium levels (hypocalcemia). Close monitoring of electrolyte levels and preventive measures, such as adequate hydration and the use of allopurinol, are important.
Nelarabine has the potential to harm an unborn baby, as indicated by animal studies and the drug’s mechanism of action. Patients who can become pregnant should use effective birth control during and for some time after treatment. A pregnancy test before starting nelarabine therapy and discussing potential risks with your healthcare provider is also recommended.
Documentation Availability
Documents required to import ATRIANCE to India?
ATRIANCE (nelarabine) injections can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing ATRIANCE around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the Generic Name for the trade name drug Atriance®?
The generic name for Atriance® is Nelarabine.
Who manufactures Atriance®?
Atriance® is produced by Novartis.
Is Atriance® FDA approved?
Yes, Atriance® received FDA approval in October 2005.
What is the dosage and form of Atriance®?
Atriance® is available as an injection: 250 mg/50 mL (5 mg/mL) for intravenous use.
What are the most common side effects of Atriance®?
Common side effects include drowsiness, nausea, vomiting, constipation, numbness or tingling, fatigue, diarrhea, headache, and blurred vision.
How to order Atriance® online in India?
Atriance® can be ordered online in India through https://rx4u.in/.
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