Cablivi(Caplacizumab-yhdp)

Cablivi(Caplacizumab-yhdp)

Cablivi

Caplacizumab-yhdp

For injection: 11 mg as a lyophilized powder in a single-dose vial.

Ablynx

Medical Use

Cablivi is a vWF-directed antibody fragment used to treat adult patients with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with immunosuppressive therapy and plasma exchange.

Recommended Dosage:

  • Initiation of Therapy: Start Cablivi injection at the beginning of plasma exchange therapy.
    • -First Day: Administer 11 mg of Cablivi via bolus IV injection at least 15 minutes before plasma exchange, followed by 11 mg via subcutaneous (SC) injection after the plasma exchange.
    • -Subsequent Days: Administer 11 mg of Cablivi via SC injection once daily after each plasma exchange.
    • -Post-Plasma Exchange Period: Continue administering 11 mg of Cablivi via SC injection once daily for one month after the final plasma exchange. If signs of persistent underlying disease are present, therapy may be extended for at least 28 days.

Discontinuation: Stop Cablivi treatment if the patient experiences more than two recurrences of aTTP while on therapy.