Medical Use
Zynlonta is a CD19-directed antibody and alkylating agent conjugate used to treat adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy. This includes diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low-grade lymphoma, and high-grade B-cell lymphoma.
Recommended Dosage: Zynlonta is administered as an intravenous infusion over 30 minutes on Day 1 of each 3-week cycle. The dosage schedule is as follows:
- 0.15 mg per kg every three weeks for the first 2 cycles.
- 0.075 mg per kg every three weeks for subsequent cycles.
Patients should be premedicated with dexamethasone 4 mg, taken orally or intravenously twice daily for 3 days, starting the day before Zynlonta treatment.
Warning & Precautions
Effusion and Edema: Patients treated with Zynlonta injection may experience severe effusion and edema. Regularly assess for new or worsening edema or effusions and manage them appropriately.
Myelosuppression: Zynlonta 10 mg injection can cause severe myelosuppression, including thrombocytopenia, neutropenia, and anemia. Monitor complete blood counts (CBC) throughout the treatment.
Infections: Fatal and severe infections, including opportunistic infections, have been reported in patients treated with Loncastuximab. Evaluate any new or worsening signs or symptoms of infection promptly.
Cutaneous Reactions: Severe skin reactions, including photosensitivity, have occurred in patients treated with Loncastuximab 10 mg injection. Monitor for new or worsening skin reactions.
Embryo-Fetal Harm: Due to its mechanism of action, Zynlonta can cause harm to a fetus if administered to a pregnant woman. It contains a genotoxic compound (SG3199) that affects actively dividing cells.
Documentation Availability
Documents required to import ZYNLONTA to India?
ZYNLONTA (loncastuximab) injections can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing ZYNLONTA (Cancer Treatment Medicines) from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the generic name for the trade name drug Zynlonta®?
The generic name for Zynlonta® is loncastuximab tesirine.
Who manufactures Zynlonta®?
Zynlonta® is manufactured by ADC Therapeutics SA.
Is Zynlonta® FDA approved?
Yes, Zynlonta® was approved by the FDA on April 23, 2021.
What is Zynlonta®?
Zynlonta® is a monoclonal antibody conjugate used to treat adult patients with relapsed or refractory diffuse large B-cell lymphoma.
What dosage and form is Zynlonta® available in?
Zynlonta® is available as an injection: 10 mg of loncastuximab tesirine-lpyl in a white to off-white lyophilized powder, supplied in a single-dose vial for intravenous administration.
What are the most common side effects of Zynlonta®?
Common side effects include skin rash, fatigue, swelling, nausea, muscle or joint pain, increased blood sugar (hyperglycemia), and changes in certain blood or laboratory tests.
What are the storage conditions for Zynlonta®?
Store Zynlonta® refrigerated at 2-8°C (36-46°F) in its original carton to protect it from light. Do not freeze or shake it.
Is it safe to buy Zynlonta® online in India?
Yes, you can safely purchase Zynlonta® online in India through https://rx4u.in/.
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