Medical Use
Rinvoq is a Janus kinase (JAK) inhibitor prescribed for:
Rheumatoid Arthritis (RA): For adults with moderate to severe RA who haven’t responded well or are intolerant to one or more TNF blockers.
Limitations: Rinvoq should not be used with other JAK inhibitors, biologic DMARDs, or potent immunosuppressants like azathioprine or cyclosporine.
Psoriatic Arthritis: For adults with active psoriatic arthritis who haven’t responded well or are intolerant to one or more TNF blockers.
Limitations: Avoid using Rinvoq with other JAK inhibitors, biologic DMARDs, or potent immunosuppressants.
Atopic Dermatitis: For adults and children aged 12 and older with moderate to severe atopic dermatitis that isn’t controlled by other systemic treatments, including biologics, or when those treatments aren’t advisable.
Limitations: Rinvoq should not be combined with other JAK inhibitors, biologic immunomodulators, or other immunosuppressants.
Ulcerative Colitis: For adults with moderate to severe ulcerative colitis who haven’t responded well or are intolerant to one or more TNF blockers.
Limitations: Rinvoq should not be used with other JAK inhibitors, biological therapies for ulcerative colitis, or potent immunosuppressants.
Ankylosing Spondylitis: For adults with active ankylosing spondylitis who haven’t responded well or are intolerant to one or more TNF blockers.
Limitations: Avoid using Rinvoq with other JAK inhibitors, biologic DMARDs, or potent immunosuppressants.
Dosage Recommendations:
- Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis: 15 mg once daily.
- Atopic Dermatitis:
- Patients aged 12 and older weighing at least 40 kg and adults under 65: Start with 15 mg once daily. If response is inadequate, consider increasing to 30 mg once daily. Discontinue if no adequate response at 30 mg. Use the lowest effective dose to maintain response.
- Adults 65 and older: 15 mg once daily.
- Ulcerative Colitis:
- Induction: 45 mg once daily for 8 weeks.
- Maintenance: 15 mg once daily. For refractory, severe, or extensive disease, 30 mg once daily may be used. Discontinue if no adequate response at 30 mg. Use the lowest effective dose to maintain response.
Tablets should be taken orally, with or without food, and swallowed whole without splitting, crushing, or chewing.
Warning & Precautions
Before starting treatment, ensure immunizations are up to date and consider evaluating for active and latent tuberculosis, liver function, viral hepatitis, and pregnancy status.
Avoid starting or interrupt treatment with Rinvoq 45 mg tablets or any other dosage if:
- -Absolute lymphocyte count is below 500 cells/mm³
- -Absolute neutrophil count is below 1000 cells/mm³
- -Hemoglobin level is below 8 g/dL
Severe and sometimes fatal infections have been reported in patients taking Upadacitinib. Monitor patients closely for signs and symptoms of infection during and after treatment. Interrupt therapy if a severe or opportunistic infection develops.
Thrombosis, including deep vein thrombosis (DVT), pulmonary embolism (PE), and arterial thrombosis, has been observed in patients treated with JAK inhibitors, including Rinvoq 30 mg tablets. Discontinue therapy and evaluate promptly if symptoms of thrombosis occur. Avoid this medication in patients at higher risk of thrombosis.
Non-melanoma skin cancers (NMSCs) may occur in patients treated with Upadacitinib. Periodic skin examinations are recommended for patients at higher risk for skin cancer. Limit exposure to sunlight/UV light by wearing protective clothing and using a broad-spectrum sunscreen.
Gastrointestinal perforations may occur with Upadacitinib 15 mg tablets or any other dosage strength. Monitor patients at risk for gastrointestinal perforation (e.g., those with a history of diverticulitis or taking NSAIDs). Promptly assess patients presenting with new onset abdominal pain to identify gastrointestinal perforation early.
Documentation Availability
Documents required to import RINVOQ to India?
RINVOQ (upadacitinib) tablets can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing RINVOQ (Cancer Treatment Medicines) from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the generic name for the trade name drug Rinvoq®?
The generic name for Rinvoq® is Upadacitinib.
Who manufactures Rinvoq®?
Rinvoq® is manufactured by AbbVie Inc.
Is Rinvoq® FDA approved?
Yes, Rinvoq® was first approved by the FDA on August 16, 2019.
What are the dosage forms and strengths of Rinvoq®?
Rinvoq® is available as extended-release tablets for oral use in the following strengths: Rinvoq 15 mg, Rinvoq 30 mg, Rinvoq 45 mg.
What are the most common side effects of Rinvoq®?
Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis: Common side effects include upper respiratory tract infections, herpes simplex, bronchitis, herpes zoster, acne, nausea, cough, fever, and headache.
-Atopic Dermatitis: Common side effects include upper respiratory tract infections, herpes zoster, acne, herpes simplex, headache, hypersensitivity, cough, folliculitis, nausea, abdominal pain, fever, weight gain, influenza, fatigue, neutropenia, muscle pain, and flu-like illness.
-Ulcerative Colitis: Common side effects during induction or maintenance include upper respiratory tract infections, increased blood creatine phosphokinase, neutropenia, elevated liver enzymes, acne, and rash.
How much does Rinvoq® cost in India?
The cost of Rinvoq® in India is reasonable and can vary. For authentic procurement, you can reach out to Rx4u team.
What are the storage conditions for Rinvoq®?
Store Rinvoq® at 2 to 25˚C (36 to 77˚F) in the original bottle to protect it from moisture.
How to order Rinvoq® online in India?
Rinvoq® can be ordered online in India through https://rx4u.in/.
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