Medical Use
Ayvakit is a kinase inhibitor prescribed for:
Gastrointestinal Stromal Tumor (GIST): It is used to treat adults with unresectable or metastatic GIST that has a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation, including the PDGFRA D842V mutation.
Advanced Systemic Mastocytosis (AdvSM): It is used to treat adult patients with AdvSM, which includes conditions such as mast cell leukemia, aggressive systemic mastocytosis, and systemic mastocytosis with an associated hematological neoplasm (SM-AHN).
Recommended Dosage:
- For GIST: The recommended dose is 300 mg taken orally once daily. Continue treatment until disease progression or unacceptable toxicity occurs.
- For AdvSM: The recommended dose is 200 mg taken orally once daily. Continue treatment until disease progression or unacceptable toxicity occurs.
Administration Instructions:
- Take Ayvakit tablets on an empty stomach, at least 60 minutes before or 120 minutes after a meal.
- If you miss a dose, do not take it within eight hours of the next scheduled dose.
- If vomiting occurs after taking a dose, do not take an additional dose; simply continue with the next scheduled dose.
Warning & Precautions
Severe intracranial hemorrhage may occur with avapritinib 300 mg treatment. Patients should be closely monitored for the risk of intracranial hemorrhage, especially those with vascular aneurysm, thrombocytopenia, or a history of intracranial hemorrhage or cerebrovascular accident within the past year.
For patients with Advanced Systemic Mastocytosis (AdvSM), a platelet count should be performed before starting therapy. Avapritinib 50 mg or any other dosage strength is not recommended for patients with AdvSM who have platelet counts below 50 x 10^9/L.
Cognitive adverse events can occur in patients taking avapritinib 25 mg tablets. Depending on the severity, avapritinib should be withheld and then resumed at the same or a reduced dose upon improvement, or permanently discontinued.
Avapritinib can cause fetal harm if administered to pregnant women. Both males and females of reproductive potential should use effective contraception during treatment with avapritinib 200 mg and for six weeks after the final dose. Women should not breastfeed during treatment with avapritinib and for two weeks following the last dose.
Documentation Availability
Documents required to import AYVAKIT to India?
AYVAKIT (avapritinib) tablets can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing AYVAKIT (Cancer Treatment Medicines) from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the Generic Name for Ayvakit®?
The generic name for Ayvakit® is avapritinib.
Who Manufactures Ayvakit®?
Ayvakit® is manufactured by Blueprint Medicines Corporation.
Is Ayvakit® FDA Approved?
Yes, Ayvakit® received FDA approval on January 9, 2020.
What is Ayvakit® Used For?
Ayvakit (avapritinib) is prescribed for adults to treat:
- Gastrointestinal stromal tumor (GIST)
- Advanced systemic mastocytosis (AdvSM)
What Dosage Forms and Strengths are Available for Ayvakit®?
Ayvakit® is available in tablet form with the following strengths: 25 mg, 50 mg, 100 mg, 200 mg, and 300 mg.
What are the Common Side Effects of Ayvakit®?
For GIST: Cognitive impairment, edema, nausea, fatigue/asthenia, vomiting, diarrhea, decreased appetite, abdominal pain, hair color changes, increased lacrimation, constipation, rash, dizziness
For AdvSM: Diarrhea, nausea, edema, fatigue/asthenia
How Much Does Ayvakit® Cost in India?
The cost of Ayvakit® in India can be reasonable. For authentic procurement, you can contact Rx4u team.
What are the Storage Conditions for Ayvakit®?
Store Ayvakit® tablets at 20°C to 25°C (68°F to 77°F). Excursions are permitted between 15°C and 30°C (59°F to 86°F).
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