Leqvio (Inclisiran)

Leqvio (Inclisiran)

Leqvio

Inclisiran

Injection: 284 mg/1.5 mL (189 mg/mL) in a single-dose prefilled syringe

Novartis

Medical Use

Leqvio (inclisiran) is a small interfering RNA (siRNA) that targets PCSK9 mRNA to lower cholesterol levels in the blood. It is prescribed for adults with primary hypercholesterolemia or mixed dyslipidemia, conditions characterized by high levels of fats, including cholesterol. A low-fat diet should be followed while taking Leqvio. It is used alongside a statin when the maximum dose of the statin is insufficient to lower cholesterol levels. It can also be combined with other cholesterol-lowering medications for individuals who cannot take statins.

Recommended Dosage:

  • -Initial Dose: The recommended dose of Leqvio is 284 mg, administered as a subcutaneous injection.
  • -Subsequent Doses: The next dose is given three months after the initial dose, followed by doses every six months.

Before starting Leqvio, patients should be on a cholesterol-lowering diet and likely taking a cholesterol-lowering medication. They should continue this diet and medication throughout the treatment with Leqvio.

Administration Instructions:

  • -Inject Leqvio subcutaneously into the upper arm, abdomen, or thigh.
  • -Avoid injecting into areas with active skin conditions such as inflammation, rashes, infections, or sunburn.

Missed Dose Instructions:

  • -If a dose is missed and it is less than three months since the last dose, administer the missed dose and continue with the regular dosing schedule.
  • -If more than three months have passed since the last dose, restart the dosing schedule: administer the initial dose, follow with a dose at three months, and then continue with doses every six months.