Medical Use
Zemdri Injection is an aminoglycoside antibiotic used to treat complicated urinary tract infections (cUTI), including pyelonephritis, in patients aged 18 and older. It is effective against the following susceptible bacteria: Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae, and Proteus mirabilis.
Recommended Dosage: Administer Zemdri at a dose of 15 mg/kg every 24 hours via intravenous (IV) infusion over 30 minutes. This dosage is for patients aged 18 and older with a creatinine clearance (CLcr) of 90 mL/min or higher. The duration of therapy should be based on the severity of the infection and the patient’s clinical response, typically up to 7 days. Dosage adjustments may be necessary based on changes in renal function during treatment.
Warning & Precautions
Nephrotoxicity: Plazomicin may cause nephrotoxicity. It is important to evaluate creatinine clearance (CLcr) before starting therapy and daily during treatment, especially in patients at higher risk, such as those with renal impairment, the elderly, and those on other potentially nephrotoxic medications. If renal function worsens, the benefits of continuing Plazomicin Injection should be reassessed.
Ototoxicity: Zemdri can cause ototoxicity, which may present as hearing loss, tinnitus, or vertigo. This risk is higher in individuals with a family history of hearing loss (excluding age-related hearing loss), those with renal impairment, and those receiving higher doses or prolonged treatment.
Neuromuscular Effects: Aminoglycosides may exacerbate muscle weakness in patients with underlying neuromuscular disorders or delay recovery of neuromuscular function in those receiving neuromuscular blocking agents. Monitor for neuromuscular blockade side effects, particularly in high-risk patients.
Pregnancy Risks: Aminoglycosides, including Zemdri 500 mg, can harm a fetus if administered to a pregnant woman. These drugs cross the placenta, and streptomycin has been associated with irreversible, bilateral congenital deafness in children exposed in utero. Pregnant patients or those who become pregnant while taking Zemdri should be informed of the potential risks to the fetus.
Hypersensitivity Reactions: Severe and sometimes fatal hypersensitivity (anaphylactic) reactions may occur with aminoglycoside antibacterial medications. Before starting Plazomicin, inquire about any previous hypersensitivity reactions to other aminoglycosides.
Clostridium difficile-associated Diarrhea (CDAD): CDAD can occur with nearly all systemic antibacterial medications, ranging from mild diarrhea to fatal colitis. Antibacterial therapy alters the normal flora of the colon, potentially leading to C. difficile overgrowth. If CDAD is suspected or confirmed, discontinue antibacterial medications not directed against C. difficile, manage fluid and electrolyte levels, supplement protein intake, assess antibacterial treatment for C. difficile, and consider surgical evaluation.
Appropriate Use: Prescribing Zemdri without a confirmed or strongly suspected bacterial infection is unlikely to benefit the patient and increases the risk of developing drug-resistant bacteria.
Documentation Availability
Documents required to import ZEMDRI to India?
ZEMDRI (Plazomicin) Injections can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing ZEMDRI (Cancer Treatment Medicines) from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the Generic Name for the trade name drug Zemdri®?
The generic name for Zemdri® is Plazomicin.
Who manufactures Zemdri®?
Zemdri® is manufactured by Achaogen, Inc.
Is Zemdri® approved by the FDA?
Yes, Zemdri® received FDA approval on June 25, 2018.
Where can I find the best price for Zemdri® in India?
For the best price on Zemdri® in India, contact the Rx4u team.
What is the dosage and form of Zemdri®?
Zemdri® is available as an injection: 500 mg/10 mL (50 mg/mL) for intravenous use.
What are the most common side effects of Zemdri®?
Common side effects include decreased renal function, diarrhea, hypertension, headache, nausea, vomiting, and hypotension.
How much does Zemdri® cost in India?
The cost of Zemdri® in India varies. To purchase this cUTI medication, you can reach out o Rx4u team.
What are the storage conditions for Zemdri®?
Store Zemdri® 500 mg/10 mL (50 mg/mL) in a refrigerator at 2°C to 8°C (36°F to 46°F).
Is it safe to buy Zemdri® online from India?
Yes, you can safely purchase Zemdri® online in India through https://rx4u.in/.
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