Medical Use
Spinraza is an antisense oligonucleotide targeting the survival motor neuron-2 (SMN2) gene, used to treat spinal muscular atrophy (SMA) in both children and adults.
Recommended Dosage:
- Initial Treatment: Administer 12 mg (5 mL) of Spinraza intrathecally. Begin with 4 loading doses: the first three doses should be given every 14 days, and the fourth dose should be administered 30 days after the third.
- Maintenance Treatment: Following the loading doses, continue with a maintenance dose of 12 mg every 4 months.
Spinraza should be administered by healthcare professionals skilled in performing lumbar punctures.
Warning & Precautions
Coagulation and Thrombocytopenia Risks:
Coagulation abnormalities and thrombocytopenia, including severe acute thrombocytopenia, have been reported following the use of some antisense oligonucleotides. Due to these risks associated with Spinraza, patients may face an increased likelihood of bleeding complications. It is essential to perform platelet counts and coagulation tests at baseline, before each Spinraza dose, and as clinically indicated.
Renal Toxicity Risks:
Renal toxicity, including potentially fatal glomerulonephritis, has also been observed with some antisense oligonucleotides. To monitor for this risk, conduct quantitative spot urine protein tests (preferably using a first-morning urine sample) at baseline and before each Spinraza dose. If urinary protein concentration exceeds 0.2 g/L, consider repeat testing and further evaluation.
Documentation Availability
Documents required to import Spinraza to India?
Spinraza (Nusinersen) injections can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing Spinraza from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the Generic Name for Spinraza?
The generic name for the trade name drug Spinraza is Nusinersen.
What are the Ingredients of Spinraza?
Spinraza contains the active ingredient Nusinersen. The inactive ingredients include calcium chloride dihydrate, magnesium chloride hexahydrate, potassium chloride, sodium chloride, sodium phosphate dibasic anhydrous, sodium phosphate monobasic dihydrate, and Water for Injection.
Is Spinraza FDA Approved?
Yes, Spinraza was approved by the FDA on December 23, 2016.
What is Spinraza?
Spinraza is an FDA-approved antisense oligonucleotide targeting the survival motor neuron-2 (SMN2) gene, used to treat spinal muscular atrophy (SMA) in both pediatric and adult patients.
What is the Dosage and Form of Spinraza?
Spinraza is supplied in single-dose vials containing 12 mg/5 mL (2.4 mg/mL).
What are the Most Common Side Effects of Spinraza?
The most common side effects include lower respiratory infections, upper respiratory infections, and constipation.
How Much Does Spinraza Cost in India?
The cost of Spinraza in India is considered reasonable. For verification and purchase, please contact the Rx4u team.
What Drug Class Does Spinraza Belong To?
Spinraza is classified as an antisense oligonucleotide.
How Does Spinraza Work?
Spinraza is designed to treat SMA caused by mutations in chromosome 5q that result in SMN protein deficiency. It works by increasing exon 7 inclusion in SMN2 mRNA transcripts, leading to the production of full-length SMN protein, as demonstrated in in vitro assays and studies in transgenic animal models of SMA.
Is it Safe to Buy Online?
Yes, you can safely purchase Spinraza online in India through https://rx4u.in/.
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