Medical Use
Xiaflex is a combination of bacterial collagenases used to treat:
- -Adult patients with Dupuytren’s contracture (palmar fibromatosis) with a palpable cord.
- -Adult males with Peyronie’s disease (penile fibrosis) with a palpable plaque and a curvature deformity of at least 30 degrees at the start of therapy.
Recommended Dosage:
Dupuytren’s Contracture: Xiaflex should be administered by a healthcare professional experienced in hand injection procedures and treating Dupuytren’s contracture. Reconstitute the lyophilized powder with the supplied diluent before use. Inject 0.58 mg of Xiaflex into each palpable Dupuytren’s cord with a contracture of a metacarpophalangeal (MP) joint or a proximal interphalangeal (PIP) joint as per the injection procedure.
- -Up to two joints in the same hand may be treated during a single visit.
- -If a contracture persists, perform a finger extension procedure 24 to 72 hours after the injection.
- -Injections and finger extension procedures can be repeated up to three times per cord at approximately 4-week intervals.
- -Treat up to two cords in the same hand during a visit. If other cords have contractures, treat them at a subsequent visit.
Peyronie’s Disease:
Xiaflex injections for Peyronie’s disease should be administered by a healthcare professional experienced in treating male urological conditions. Reconstitute the lyophilized powder with the supplied diluent before use.
- -A treatment cycle typically includes two Xiaflex injection procedures and a penile modeling procedure.
- -Induce a penile erection, possibly using a single intracavernosal injection of 10 or 20 micrograms of alprostadil.
- -With the penis erect, identify and mark the target area in the Peyronie’s plaque for injection. Ensure the penis is flaccid before administering the injection.
- -Administer Xiaflex 0.58 mg into the target plaque once on each of two days, spaced 1 to 3 days apart, following the specified injection procedure.
- -Perform the penile modeling procedure 1 to 3 days after the second injection of each Peyronie’s disease treatment cycle.
- -For each plaque causing the curvature deformity, up to four treatment cycles can be given. Each cycle may be repeated approximately every six weeks. If the curvature deformity is less than 15 degrees after the first, second, or third treatment cycle, or if further treatment is not clinically necessary, then proceed with the subsequent treatment cycles accordingly.
Warning & Precautions
Skin lacerations requiring skin grafts may occur after finger extension procedures. Any signs or symptoms indicating serious injury to the injected finger or hand should be promptly assessed, as surgical intervention might be necessary.
Similarly, signs or symptoms indicating severe injury to the penis should be promptly evaluated to check for corporal rupture or severe penile hematoma, which may also require surgical intervention.
Injecting Xiaflex into collagen-containing structures like the corpora cavernosa of the penis can cause damage, potentially leading to penile fracture. Therefore, Xiaflex should only be injected into the Peyronie’s plaque. Care must be taken to avoid injecting into blood vessels, the urethra, nerves, corpora cavernosa, or other collagen-containing structures of the penis.
Some patients with Dupuytren’s contracture have developed IgE-anti-drug antibodies in greater proportions and higher titers with successive collagenase clostridium histolyticum injections. Health specialists should be prepared to manage severe allergic reactions following such injections.
The efficacy and safety of Xiaflex treatment in patients taking anticoagulant medications (other than low-dose aspirin, up to 150 mg daily) within 7 days prior to using Xiaflex are unknown. It is also recommended to avoid using this injection in patients with coagulation disorders, including those on concomitant anticoagulants (except for low-dose aspirin).
Documentation Availability
Documents required to import XIAFLEX to India?
XIAFLEX (collagenase clostridium histolyticum) injection can be imported by patients or treating physicians on behalf of patients. The following documentation is required to import the product:
- (i)2 ID proofs along with PAN card details along with attested scanned copies
- (ii)Valid doctor prescription scanned copy
- (iii)Doctor’s MCI number
- (iv)Doctor’s mobile number
- (v)Patients diagnostic reports
How is the order confirmed?
The order will be confirmed only after the receipt of:
- (i)The above-mentioned documents and drug availability.
- (ii)Import permit if applicable.
Sourcing & Delivery
The Rx4U team has extensive experience in sourcing XIAFLEX (Cancer Treatment Medicines)) from around the world, ensuring global access to the best available treatments for our customers. We are dedicated to promptly dispensing any valid prescription. All prescriptions are verified and dispatched directly to the patient’s address. Our patients are our top priority, and we strive to improve their lives through our services.
FAQ
What is the generic name for Xiaflex®?
The generic name for Xiaflex® is Collagenase Clostridium Histolyticum.
Who manufactures Xiaflex®?
Xiaflex® is manufactured by BioSpecifics Technologies Corp.
Is Xiaflex® FDA approved?
Yes, Xiaflex® received FDA approval on February 3, 2010.
Where can I find the best price for Xiaflex® in India?
For the best price on Xiaflex® in India, contact Rx4u team.
What is the dosage and form of Xiaflex®?
Xiaflex® is available in single-use glass vials containing 0.9 mg for intralesional administration.
What are the common side effects of Xiaflex®?
Common side effects include:
- Dupuytren’s Contracture: Peripheral edema (swelling of the injected hand), injection site hemorrhage, injection site reaction, contusion, and pain in the injected extremity.
- Peyronie’s Disease: Penile hematoma, penile pain, and penile swelling.
How much does Xiaflex® cost in India?
The cost of Xiaflex® injections in India varies. For authentic procurement, you can order on www.rx4u.in.
What are the storage conditions for Xiaflex®?
Before reconstitution, store Xiaflex® vials and diluent in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. The reconstituted solution can be kept at room temperature (20°C to 25°C/68°F to 77°F) for up to 60 minutes or refrigerated at 2°C to 8°C (36°F to 46°F) for up to 4 hours before administration.
Is it safe to buy Xiaflex® online from India?
Yes, you can safely purchase Xiaflex® (collagenase clostridium histolyticum) online at the best price from https://rx4u.in/
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